Antiestrogens: Future Prospects
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چکیده
Triphenylethylene structures similar to tamoxifen (Nolvadex) were first used in the 1940s, but in comparison to synthetic and natural estrogens used at that time, they were not particularly potent antitumor agents. [1,2] Tamoxifen was introduced into the clinic in 1969. Because of its much improved toxicity profile over the estrogens and androgens in use at that time, it rapidly gained acceptance as the endocrine treatment of choice for advanced breast cancer and subsequently as adjuvant therapy.[3-5]
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Antiestrogens: Future Prospects
Triphenylethylene structures similar to tamoxifen (Nolvadex) were first used in the 1940s, but in comparison to synthetic and natural estrogens used at that time, they were not particularly potent antitumor agents. [1,2] Tamoxifen was introduced into the clinic in 1969. Because of its much improved toxicity profile over the estrogens and androgens in use at that time, it rapidly gained acceptan...
متن کاملAntiestrogens: Future Prospects
Triphenylethylene structures similar to tamoxifen (Nolvadex) were first used in the 1940s, but in comparison to synthetic and natural estrogens used at that time, they were not particularly potent antitumor agents. [1,2] Tamoxifen was introduced into the clinic in 1969. Because of its much improved toxicity profile over the estrogens and androgens in use at that time, it rapidly gained acceptan...
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تاریخ انتشار 2017